Do not mix an MAOi, including methylene blue, with other strongly serotonergic medications like SSRI/SNRIs, tramadol, meperidine, or dextromethorphan due to the risk of serotonin toxicity.
Which drug combinations are high-risk for serotonin syndrome/toxicity? Read More »
Serotonin syndrome is a toxidrome caused by a recent increase in serotonergic drug exposure. It is defined by the clinical triad of neuromuscular excitation, altered mental status, and autonomic excitation.
How do you recognize the spectrum of serotonin syndrome/toxicity? Read More »
SSRIs rarely cause hyponatremia, but the risk is higher in older adults and people taking thiazide diuretics. Check a Na in a patient who becomes confused or more lethargic soon after starting an SSRI.
